Richard S Hotchkiss Selected Research

Interleukin-7 (Interleukin 7)

7/2021	Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report.
6/2021	IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis.
4/2021	In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019.
1/2020	Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.
1/2020	Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19).
1/2018	Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.
1/2018	Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.
1/2017	Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.
4/2015	Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression.
1/2015	Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes.

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Richard S Hotchkiss Research Topics

Disease

80	Sepsis (Septicemia) 01/2022 - 01/2002
17	Neoplasms (Cancer) 10/2019 - 05/2007
13	Pneumonia (Pneumonitis) 01/2017 - 05/2003
10	Infections 01/2022 - 09/2006
10	Critical Illness (Critically Ill) 01/2022 - 05/2004
8	COVID-19 01/2022 - 01/2020
8	Inflammation (Inflammations) 01/2021 - 05/2002
6	Septic Shock (Toxic Shock Syndrome) 01/2018 - 01/2010
5	Peritonitis 01/2017 - 12/2002
4	Lymphopenia (Lymphocytopenia) 07/2021 - 11/2014
4	Wounds and Injuries (Trauma) 06/2021 - 12/2011
4	Mycoses (Diseases, Fungus) 06/2021 - 08/2012
4	Communicable Diseases (Infectious Diseases) 10/2018 - 03/2013
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2012 - 07/2007
4	Adenocarcinoma 03/2010 - 07/2007
3	Hypersensitivity (Allergy) 08/2022 - 08/2012
3	Cytokine Release Syndrome 12/2020 - 01/2019
3	Fever (Fevers) 01/2019 - 09/2011
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 09/2017 - 04/2016
3	Acute Lung Injury 02/2008 - 11/2003
2	Migraine Disorders (Migraine) 08/2022 - 01/2020
2	Severe Acute Respiratory Syndrome 04/2021 - 03/2021
2	Bacterial Infections (Bacterial Infection) 01/2021 - 01/2018
2	Human Influenza (Influenza) 12/2020 - 05/2020
2	Hepatitis 01/2018 - 08/2012
2	Virus Diseases (Viral Diseases) 01/2018 - 04/2015
2	Coinfection 01/2017 - 10/2016
2	Candidiasis (Moniliasis) 01/2017 - 08/2012
2	Arthritis (Polyarthritis) 09/2012 - 02/2010
1	Immune System Diseases (Immune Disorders) 01/2022
1	Brain Injuries (Brain Injury) 01/2022
1	Soft Tissue Infections 06/2021

Drug/Important Bio-Agent (IBA)

23	CytokinesIBA 12/2020 - 05/2003
16	Interleukin-7 (Interleukin 7)IBA 07/2021 - 04/2010
11	LigandsIBA 01/2021 - 07/2007
10	Proteins (Proteins, Gene)FDA Link 05/2020 - 01/2002
9	Biomarkers (Surrogate Marker)IBA 10/2019 - 03/2013
8	Interleukin-6 (Interleukin 6)IBA 01/2022 - 02/2004
8	Immunologic Adjuvants (Immunologic Adjuvant)IBA 07/2021 - 03/2013
8	salicylhydroxamic acid (SHAM)IBA 01/2017 - 09/2005
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 10/2005
6	Interleukin-10 (Interleukin 10)IBA 08/2022 - 12/2006
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 05/2003
5	Peptides (Polypeptides)IBA 01/2021 - 05/2006
5	Pharmaceutical PreparationsIBA 01/2019 - 07/2010
5	sigma-2 receptorIBA 01/2012 - 07/2007
4	AntibodiesIBA 01/2021 - 05/2013
4	HLA-DR Antigens (HLA-DR)IBA 01/2021 - 10/2016
4	InterferonsIBA 12/2020 - 12/2011
4	CaspasesIBA 07/2007 - 05/2004
3	Interferon-gamma (Interferon, gamma)IBA 05/2020 - 05/2013
3	LipopolysaccharidesIBA 10/2016 - 11/2003
3	Indicators and Reagents (Reagents)IBA 09/2013 - 08/2010
3	SV119IBA 01/2012 - 07/2007
3	Caspase 3 (Caspase-3)IBA 08/2009 - 01/2002
3	Death Domain ReceptorsIBA 03/2007 - 04/2005
2	Nitroglycerin (Dynamite)FDA LinkGeneric 08/2022 - 01/2020
2	Interleukin-2 (IL2)IBA 08/2022 - 01/2020
2	ElementsIBA 01/2022 - 09/2005
2	Antiviral Agents (Antivirals)IBA 07/2021 - 01/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 04/2021 - 12/2011
2	Programmed Cell Death 1 ReceptorIBA 01/2021 - 01/2019
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 12/2020 - 05/2020
2	HLA Antigens (Human Leukocyte Antigens)IBA 12/2020 - 10/2016
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 12/2020 - 01/2012
2	NivolumabIBA 10/2019 - 01/2017
2	RNA (Ribonucleic Acid)IBA 10/2019 - 04/2007
2	Immune Checkpoint InhibitorsIBA 10/2019 - 01/2019
2	AntipyreticsIBA 01/2019 - 10/2013
2	Interleukin-17 (Interleukin 17)IBA 01/2017 - 11/2010
2	Interleukin-15 (Interleukin 15)IBA 04/2014 - 02/2010
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2014 - 01/2014
2	Gemcitabine FDA Link 08/2009 - 03/2009
2	Small Interfering RNA (siRNA)IBA 08/2009 - 08/2008
2	InterleukinsIBA 12/2006 - 10/2005
2	IronIBA 09/2005 - 05/2004
2	EndotoxinsIBA 05/2004 - 05/2002
1	Transforming Growth Factors (Transforming Growth Factor)IBA 08/2022
1	Neutralizing AntibodiesIBA 08/2022
1	durlobactamIBA 01/2022
1	LactamsIBA 01/2022
1	Interferon Type IIBA 07/2021
1	Toll-Like Receptor 3IBA 07/2021
1	dexamethasone 21-phosphate FDA LinkGeneric 04/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 04/2021
1	Angiotensin-Converting Enzyme 2IBA 03/2021

Therapy/Procedure

44	Therapeutics 08/2022 - 04/2003
22	Punctures 01/2022 - 05/2002
22	Ligation 01/2022 - 05/2002
11	Immunotherapy 07/2021 - 07/2010
5	Critical Care (Surgical Intensive Care) 02/2016 - 11/2005
3	Artificial Respiration (Mechanical Ventilation) 01/2022 - 09/2013
3	Mechanical Ventilators (Ventilator) 09/2017 - 04/2016
2	Precision Medicine 07/2021 - 04/2021
2	Immunomodulation 04/2021 - 10/2016
2	Subcutaneous Injections 03/2010 - 05/2004
2	Drug Therapy (Chemotherapy) 08/2009 - 03/2009
1	Induced Hyperthermia (Thermotherapy) 01/2022
1	Resuscitation 01/2022
1	Debridement 06/2021